HIV and the brain – Dr. Simon Rackstraw Welcome to your HIV and the brain - Dr. Simon Rackstraw The incidence of HIV associated dementia has increased since the widespread introduction of HAART Yes No Low nadir CD4 count is associated with HIV associated cognitive impairment Yes No Signs of psychomotor slowing and poor executive functioning are pointers towards a diagnosis of Alzheimer's rather than HIV associated cognitive decline Yes No Does level of vocabulary decline with age? Yes No Should patients with HIV associated cognitive change be treated with an Efavirenz containing regimen according to the BHIVA guidelines? Yes No Was there evidence of cognitive change if changing from an FTC/TDF regime to a FTC/TAF regime in a recent study? Yes No Has treatment with Dolutegravir been associated with neuropsychiatric side effects in real life cohorts? Yes No Time is Up!