HIV/Hep C Co-infection Dr. Ranjababu Kulsegram Welcome to your HIV/Hep C Co-infection Dr. Ranjababu Kulsegram What percentage of patients with acute hepatitis C will spontaneously clear the virus with persistence of the antibody? a. 15% b. 20% c. 25% d. 85% e. None of the above What is the most prevalent Hepatitis C genotype globally? a. Genotype 3 b. Genotype 4 c. Genotype 5 d. Genotype 1 e. Equal prevalence of Genotype 1 and 3 Which of these investigations is considered to be the gold standard measure of liver fibrosis? a. Liver biopsy b. Elastography/Fibroscan c. Serum biomarkers - ARFI/FIB-4 d. Ultrasound scan e. CT scan Which of these direct acting antivirals (DAAs) are not available as a fixed dose combination single tablet regimen for the management of Hepatitis C? a. Velpatasivir/Sofosbuvir b. Voxilaprevir/Velpatasvir/Sofosbuvir c. Glecaprevir/Pibrentasvir d. Elbasvir/Grazoprevir e. Ledipasvir/Ombitasvir With the success of DAA's in the management of Hepatitis C, many patients achieve sustained virological response (SVR). Goals of treatment have now moved towards focusing on improving both hepatic and extrahepatic clinical outcomes. Which of these factors affect liver wellness after SVR? a. Obesity b. Gender c. Smoking d. High cardiovascular risk e. Reduced renal function Time is Up!