TB/HIV Dr Graham Cooke Welcome to your TB/HIV Dr Graham Cooke Which of the following statements is true?a. Mycobacterium tuberculosis (MTB) is a disease that usually affects the lungsb. The most common site of tuberculosis is the lymph nodesc. A positive Mantoux skin test means a person has MTB in their bodyd. Smear microscopy is the most commonly used test to diagnose tuberculosise. Latent TB infection always requires treatment to prevent progression to diseases Which of the following is NOT true?a The number of newly notified TB cases each year is going down in the UKb. HIV prevalence in new TB cases in the UK is under 10%c. Starting HIV treatment has little impact on risk of tuberculosis in people living with HIVd. The sensitivity of immune based tests (IGRAS) to detect latent TB infection is affected by HIVe. Smear microscopy is less sensitive for tuberculosis in HIV positive Individuals with low CD4 counts Which of these is TRUE?a. Co-administration of rifampicin requires dose adjustment of NRTIs, NNRTs and protease inhibitorsb. Rifabutin cannot be co-administered with protease inhibitorsc. Unmasking IRIS can be the consequence of undiagnosed subclinical tuberculosisd. IRIS has a high mortality ratee. There is no randomised evidence to support the use of steroids in IRIS Which of the following are TRUE?a. A rifampicin sensitive organism cannot be classified as MDR-TBb. The most common monoresistance in the UK is to rifampicinc. XDR-TB can still be sensitive to amikacind. Over 5% of tuberculosis in the UK is MDR-TBe. There are fewer than 100 cases of MDR-TB notified in the UK each year Which of these are TRUE? a. Most drug resistance in the UK develops in patients who do not take their treatment as prescribed b. Individualised treatment of MDR-TB is associated with better outcomes than standardised treatments c. 20% of individuals hospitalised with MDR-TB in the UK lose their homes d. Bedaquiline is the only new TB drug in the last 20 years e. Linezolid is recommended by WHO as a first line treatment for MDR-TB Time is Up!